Endocrine Abstracts

The pharmaceutical armamentarium available for contraception is remarkable and extraordinary progress has been achieved since 1960, when the first hormonal contraceptive, Enovid, was approved in the USA. However, the demand for new methods, for improvement of existing methods, and easier availability, remains extraordinary. Indeed, the number of unintended pregnancies is still too high, averaging 40% of all pregnancies. In addition, 50% of these pregnancies are followed by abo...

50 years after the approval in the USA of the first oral contraceptive, it is quite remarkable that this considerable medical advance, may be the greatest medical discovery in the last century, the combined pill, which replaced condoms and unreliable natural methods, is still a matter of controversy. Recently, fear for hormones is more and more common in women in relation with the pill scares observed in UK and in France, and in relation with the media noise on Endocrine disru...

Objective: Ulipristal acetate or UPA (PGL4001, formerly CDB-2914) is an oral SPRM with the potential to be the first in a new treatment class for uterine fibroids. As treatment with first-generation SPRMs led to modification of adrenal and thyroid function and changes in prolactin secretion and because UPA binds to the glucocorticoid receptor, we report here a detailed investigation of the endocrine effects of UPA.Methods: Endocrine function was assessed...

Background: Radioactive iodine therapy (RAI) is a classical therapeutic approach in patients with differentiated thyroid carcinoma (DCT). Few data are currently available on RAI’s potential impacts on testicular function.Design: A longitudinal prospective multi-center study (PHRC N°P040419) included male patients before a single radioiodine dose of 3.7 GBq of I 131 (V0), at 3 months (V3) and 13 months (V13) post treatment.<p clas...

Normosmic congenital hypogonadotropic hypogonadism (nCHH) is a rare reproductive disease leading to lack of puberty and infertility. Loss-of-function mutations of GNRH1 gene are a very rare cause of autosomal recessive nCHH. R31C GNRH1 is the only missense mutation that affects the conserved GnRH decapeptide sequence. This mutation was identified in a CpG islet in nine nCHH subjects from four unrelated families, giving evidence for a putative ‘hot spot&#...

Introduction: There are contradictory results concerning bone mineral density status in adult patients with congenital adrenal hyperplasia. To resolve this issue, we hypothesized that there could be a correlation between BMD and a total cumulative glucocorticoid dose from the diagnosis in early infancy to adulthood. We then conducted a retrospective in a referral centers for CAH. Thirty-eight adult patients (28 women, 10 men, aged 16–39 years) suffering from CAH and treat...